More than 20 veterinary clinics in osteosarcoma vaccine clinical trial. We all know that the veterinary science world is working on the development of a ground-breaking vaccine against the devastating osteosarcoma. This evolutionary vaccine is an immunotherapy treatment and it is designed as an alternative therapy over amputation and chemotherapy.
The initial results from the pilot study for this vaccine were very promising and now the study is becoming even bigger and its aim is to test the efficacy and the safety of the vaccine.
The conditional license for the vaccine, Live Listeria Vector AT-014, is given to the pharmaceutical company Aratana Therapeutics. The company expanded the clinical trials and included more than 20 veterinary oncology clinics across the United States so it can receive the full licensure.
The initial testing of the vaccine was performed on 18 dogs and the ones that received the vaccine got to live twice as long as the matched control group. The median survival times were 956 days compared to 423 days without the vaccine.
The new vaccine is designed to carry osteosarcoma markers on a harmless Listeria bacterium.
Osteosarcoma is a bone tumor that is malignant in nature and is the most common type of bone tumor among dogs and cats. In fact, osteosarcoma the tumor identified in more than 95% of pets with bone cancer. A specific cause for the occurrence of osteosarcoma haven’t been found, but it is believed, that pets with some kind of previous bone damage are more at risk (fractures, radiation, bone diseases, orthopedic implants or surgery).
It is very peculiar that this disease affects dogs and cats very differently. In dogs, osteosarcoma is an extremely aggressive malignant tumor, and meanwhile, in cats, it’s with benign characteristics and only in 3rd of the cases.
Read the original article and the full list of veterinary oncology clinics “20-plus clinics to participate in expanded osteosarcoma vaccine clinical trial”
If you want to learn more about osteosarcoma, read “Osteosarcoma in dogs and cats“