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Vaccine for osteosarcoma in dogs

Interview with Dr. Kibble - New York City Veterinarian
Lab Animal Clinical Management: AVMA Clinical Task Checklists- Video by Victoria Birch

Osteosarcoma is the most common malignant tumor diagnosed in dogs. This type of malignant tumor typically affects older dogs of larger breeds, but cases of 2-year-old dogs diagnosed with osteosarcoma have been reported.

Symptoms of osteosarcoma are rotating around the bone that is affected by it. The most common symptom is intermittent lameness without any apparent trauma or injury. In some cases, the bone can become so fragile so it may fracture with minor trauma. Most common bones to get affected by osteosarcoma are the distal radius, distal femur, proximal tibia and proximal humerus.

Aratana Therapeutics Inc. has been working on a vaccine against osteosarcoma in dogs, and on December 20, 2017, announced that has been granted a conditional license by the Department of Agriculture’s Center for Veterinary Biologics.

The vaccine is developed with a Listeria-based antigen delivery system created by Advaxis Inc. The vaccine is essentially a modified-live, attenuated Listeria strain that can activate T-cells, which are then directed to fight cancer cells.

 

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